PHARMACOKINETIC STUDIES OF DIOSMIN AND DIOSMETIN IN PERFUSED-RAT-LIVER

1. The kinetics and metabolism of diosmin and diosmetin were investiga ted in the isolated perfused rat liver in order to assess the role of the liver. 2. Diosmetin and especially diosmin disappeared quickly fro m the perfusion medium. 3. Both flavonoids were rapidly metabolized an d diosmetin was partly excreted in bile as the glucuronide and sulphat e and diosmin was partly excreted in bile as such and as the glucuroni de conjugate. 4. Diosmin and diosmetin did not appear to affect variou s parameters of liver function.