A 40-year-old man was working in an enclosed space at a nuclear power
plant when a high-temperature, high-pressure steam pipe ruptured, burn
ing 60% of his body. Sudden hoarseness prompted endotracheal intubatio
n, and edematous vocal cords were seen. The initial chest radiograph w
as normal (Fig. 1A). Normal gas exchange was maintained, and the patie
nt was extubated on the second hospital day. Subsequent chest radiogra
phs showed bibasilar atelectasis and mild perihilar pulmonary edema. T
he patient responded well to treatment for his burns but on the sevent
h day abruptly became dyspneic, hypoxic, and hypotensive. Cardiopulmon
ary arrest followed, and the patient died despite resuscitative effort
s. Autopsy showed a severe necrotizing laryngotracheobronchitis (Fig.
1B). The airway mucosa from the hypopharynx and larynx to the trachea
and large bronchi was markedly hyperemic and edematous, with a loose,
friable yellow-gray pseudomembrane. The lungs were edematous, but no o
ther cardiopulmonary abnormalities were present. Death was attributed
to acute airway occlusion by the sloughed pseudomembrane.