Background and Purpose Transesophageal echocardiography has a high yie
ld for detecting potential cardiac sources of embolism in patients wit
h clinical risk factors for cardioembolism or unexplained stroke. The
yield in other stroke subtypes is unknown. Methods We classified 145 c
onsecutively admitted patients into stroke subtypes based on clinical
findings, brain imaging, and carotid ultrasound. Both transesophageal
and transthoracic echocardiography were performed to detect left atria
l thrombi, spontaneous echo contrast, atrial septal aneurysm, interatr
ial shunts, ventricular thrombus or aneurysm, and myxomatous mitral va
lve. Results Transesophageal echocardiography documented at least one
of these findings in 46% of the patients compared with an 8% yield on
the transthoracic study (P=.002). The yield of transesophageal echocar
diography was substantial in all stroke subgroups. Patients with clini
cal risk factors for cardiac embolism had the highest frequency of spo
ntaneous echo contrast (P=.001). Atrial septal aneurysms were most fre
quent in patients with lacunar syndromes (P=.012), and interatrial shu
nts were common in all stroke subtypes. Conclusions Transesophageal ec
hocardiographic findings vary considerably between stroke subgroups.