BETA-GAMMA-TRANSDUCIN STIMULATES HYDROLYSIS AND SYNTHESIS OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE IN BOVINE ROD OUTER SEGMENT MEMBRANES

Authors
GRIGORJEV IV GRITS AI ARTAMONOV I BARANOVA LA VOLOTOVSKI ID
Citation
Iv. Grigorjev et al., BETA-GAMMA-TRANSDUCIN STIMULATES HYDROLYSIS AND SYNTHESIS OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE IN BOVINE ROD OUTER SEGMENT MEMBRANES, Biochimica et biophysica acta. Molecular cell research, 1310(1), 1996, pp. 131-136
Citations number
37
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular cell research → ACNP
ISSN journal
01674889
Volume
1310
Issue
1
Year of publication
1996
Pages
131 - 136
Database
ISI
SICI code
0167-4889(1996)1310:1<131:BSHASO>2.0.ZU;2-Y
Abstract
T beta gamma was shown to stimulate the hydrolysis and synthesis of Pt dInsP(2) in dark-adapted bovine retinal rod outer segments. In contras t, T alpha(GDP) blocked the effect of beta gamma-transducin. It was al so demonstrated that T beta gamma was a stimulator of P-32 incorporati on into PtdInsP(2) in ROS. These findings explain the modulating actio ns of GTP and light on PtdInsP(2) hydrolysis and synthesis in ROS. The possible existence of cross-talk between the cGMP and phosphoinositid e cascades in retinal rods was discussed.