PEPTIDE MODULATION OF ALLERGEN-SPECIFIC IMMUNE-RESPONSES

In vitro peptide stimulation of allergen-reactive T-helper type 1 and type 0 cells, in the absence of costimulatory signals, induces anergy that is accompanied by the modulation of cell surface phenotype and ch anges in cytokine production. In experimental animal models, the admin istration of allergen-derived peptides may result in the downregulatio n of cytokine and antibody production, which is preceded by transient activation of CD4+ T cells, without the induction of effector immunity . Preliminary results of clinical trials using allergen-derived peptid es for desensitization are becoming available and should provide some insight into the efficacy of peptide therapy In man.