EPITHELIAL EXPRESSION AND CHROMOSOMAL LOCATION OF HUMAN TLE GENES - IMPLICATIONS FOR NOTCH SIGNALING AND NEOPLASIA

Citation
Yl. Liu et al., EPITHELIAL EXPRESSION AND CHROMOSOMAL LOCATION OF HUMAN TLE GENES - IMPLICATIONS FOR NOTCH SIGNALING AND NEOPLASIA, Genomics, 31(1), 1996, pp. 58-64
Citations number
26
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
08887543
Volume
31
Issue
1
Year of publication
1996
Pages
58 - 64
Database
ISI
SICI code
0888-7543(1996)31:1<58:EEACLO>2.0.ZU;2-C
Abstract
The TLE genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway. This pathway controls a number of dif ferent cell-fate choices in invertebrates and vertebrates. We are inte rested in investigating the functions of the TLE gene family during ep ithelial determination and carcinogenesis. We show that expression of individual TLE genes correlates with immature epithelial cells that ar e progressing toward their terminally differentiated state, suggesting a role during epithelial differentiation. In both normal tissues and conditions resulting from incorrect or incomplete maturation events, s uch as metaplastic and neoplastic transformations, TLE expression is e levated and coincides with Notch expression, implicating these molecul es in the maintenance of the undifferentiated state in epithelial cell s. We also show that TLE1 and TLE2 are organized in a tandem array at chromosomal location 19p13.3, while TLE3 maps to 15q22. (C) 1996 Acade mic Press, Inc.