QUANTITATIVE ASSAY OF VERAPAMIL IN DRUGS AND SERUM BY CAPILLARY ISOTACHOPHORESIS

Authors
BUZINKAIOVA T SKACANI I NETRIOVA J
Citation
T. Buzinkaiova et al., QUANTITATIVE ASSAY OF VERAPAMIL IN DRUGS AND SERUM BY CAPILLARY ISOTACHOPHORESIS, Die Pharmazie, 50(12), 1995, pp. 799-800
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
12
Year of publication
1995
Pages
799 - 800
Database
ISI
SICI code
0031-7144(1995)50:12<799:QAOVID>2.0.ZU;2-Z
Abstract
Experimental conditions for a simple capillary isotachophoresis (ITP) with conductometric detection have been created for the determination of verapamil in drugs and serum. The limit of detection (LD) was 80 ng . cm(-3) for standard verapamil solution. Under optimal experimental conditions and instrumental comparison, the LD of verapamil in serum w as 420 ng . cm(-3) without sample pretreatment. To lower the LD of ver apamil in serum a liquid-liquid extraction was used. The high recovery (more than 94%) facilitated the verapamil ITP analysis at the therape utic concentration.