GENETIC-EVIDENCE FOR THE NEURONAL NITRIC-OXIDE SYNTHASE GENE (NOS1) AS A SUSCEPTIBILITY LOCUS FOR INFANTILE PYLORIC-STENOSIS

Authors
CHUNG E CURTIS D CHEN G MARSDEN PA TWELLS R XU WM GARDINER M
Citation
E. Chung et al., GENETIC-EVIDENCE FOR THE NEURONAL NITRIC-OXIDE SYNTHASE GENE (NOS1) AS A SUSCEPTIBILITY LOCUS FOR INFANTILE PYLORIC-STENOSIS, American journal of human genetics, 58(2), 1996, pp. 363-370
Citations number
38
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
58
Issue
2
Year of publication
1996
Pages
363 - 370
Database
ISI
SICI code
0002-9297(1996)58:2<363:GFTNNS>2.0.ZU;2-X
Abstract
The etiological role of the gene for neuronal nitric oxide synthase (N OS1) in infantile pyloric stenosis (PS) was investigated by analysis o f two intragenic polymerphisms (NOS1a and NOS1b) in 27 families. There was significant overall transmission disequilibrium between PS and NO S1a (P = .006). Consideration of each allele independently revealed a highly significant tendency for allele 7 (210 bp) to be preferentially transmitted to the affected offspring (P = .0006). These observations suggest that NOS1 is a susceptibility Locus for PS.