LUNG-CANCER ASSOCIATED WITH USUAL INTERSTITIAL PNEUMONIA

Citation
H. Matsushita et al., LUNG-CANCER ASSOCIATED WITH USUAL INTERSTITIAL PNEUMONIA, Pathology international, 45(12), 1995, pp. 925-932
Citations number
14
Categorie Soggetti
Pathology
Journal title
ISSN journal
13205463
Volume
45
Issue
12
Year of publication
1995
Pages
925 - 932
Database
ISI
SICI code
1320-5463(1995)45:12<925:LAWUIP>2.0.ZU;2-0
Abstract
There were 83 cases of usual interstitial pneumonia (UIP) in 3712 cons ecutive autopsy cases during 1972 to 1992 in Toranomon Hospital. Prima ry lung cancer had arisen in 40 cases of UIP in that period. The preva lence of lung cancer (48.2%) in UIP was significantly higher than that of lung cancers (9.1%) in the age-matched general population without UIP (P < 0.001). The prevalence of association of multiple lung cancer in UIP (20.0%) was also significantly increased. Thus, UIP showed a r emarkable potency to develop lung cancers. The lung cancer cases in UI P had obvious smoking habits. Both the rates of smokers and the quanti ty of smoking were significantly increased in the lung cancer cases in UIP (P < 0.05). There was a distinct anatomical distribution of lung cancer in UIP. Most cancers in UIP (98%) arose in the peripheral area of the lung (P < 0.001, compared to lung cancer cases without UIP) wit h close relation to the honeycombing lesion. Studies on surgical speci mens with small cancers showed that most tumors in UIP arose in the bo rder area between honeycombing and the non-fibrotic area. Thus, the fr ont of the remodeling of the lung is suspected to be a potential field of developing lung cancer, The chronic inflammatory process resulting in the remodeling of the lung may play an important part in the devel opment of lung cancer in UIP under the circumstance of heavy smoking.