H. Usuda et al., PERIPHERAL LUNG CARCINOMAS ASSOCIATED WITH CENTRAL FIBROSIS AND MIXEDSMALL-CELL AND OTHER HISTOLOGIC COMPONENTS, Pathology international, 45(12), 1995, pp. 940-946
Three cases of peripheral small cell lung carcinoma (SCLC) with centra
l fibrosis are presented. Central fibrosis is usually present in adeno
carcinomas, Cases 1 and 2 are combined SCLCs with components of papill
ary adenocarcinoma, and case 3 is a mixed SCLC with a large cell compo
nent. Small cell components showed intermediate cell type in all cases
. In cases 1 and 2, there was a gradual transition between small cell
carcinoma and papillary adenocarcinoma. Small cell components showed G
rimelius argyrophilia, but other neuroendocrine markers such as neuron
specific enorase, chromogranin A, Leu-7 and synaptophysin were negativ
e. The chest X-ray examination of case 1 demonstrated rapid enlargemen
t of a tumor shadow, which was present two years before, for a recent
year, Central fibrosis, coexistence of small cell carcinoma and papill
ary adenocarcinoma, and a change of growth rate in the chest X-ray may
suggest that some SCLC derive from papillary adenocarcinomas.