ELECTROCONVULSIVE SHOCK DECREASES EXCITATORY RESPONSES TO SEROTONIN IN THE CAUDATE-NUCLEUS OF THE RAT

Contreras Carlos M., Guillermo Sanchez Estrada, Miguel Molina Hernande z and Ma. Luisa Marvan, Electroconvulsive shock decreases excitatory r esponses to serotonin in the caudate nucleus of the rat. Prog. Neuro-P sychopharmacol & Biol Psychiat. 1994, 18(1): 193-199. 1. The present s tudy explored the changes on the firing rate of caudate neurons, and t he response to serotonin locally applied in rats submitted to electroc onvulsive shock. 2. Electroconvulsive shock diminished the firing rate of caudate neurons and blocked the excitatory response produced by se rotonin in a small amount of serotonin-sensitive neurons. 3. Results a re likely to be related with transient changes in the receptor's affin ity and dissociation constants, which may impinge on immediate memory retrieval.