LOCALIZATION OF THE GENE FOR HUMAN HEART FATTY-ACID-BINDING PROTEIN TO CHROMOSOME 1P32-1P33

Heart fatty acid binding protein (hFABP) is an abundant 14-kDa cytosol ic protein thought to be involved in trafficking of fatty acids from t he plasma membrane to sites of beta-oxidation in mitochondria and pero xisomes and to the endoplasmic reticulum for lipid synthesis. A human hFABP cDNA isolated by polymerase chain reaction was used as a probe f or in situ hybridization to metaphase chromosomes. A fragment of the g ene for human hFABP was used as a probe for fluorescence in situ hybri dization to metaphase chromosomes. The cDNA and genomic probes both lo calized the gene for human hFABP to chromosome 1p32-1p33.