ANALYSIS OF A 26 KB REGION ON THE LEFT ARM OF YEAST CHROMOSOME-XV

In the framework of the EC programme for sequencing yeast chromosome X V, we have determined the nucleotide sequence of a 26 kb region. Subse quent analysis revealed 13 non-overlapping open reading frames, three of which correspond to known yeast genes. A pair of tRNA genes associa ted with remnant Ty elements were localized in this region. From struc tural parameters and/or similarity searches with entries in the curren t data libraries, a preliminary functional assessment of several of th e putative novel gene products can be made. The gene density in this r egion amounts to one gene in 2 kb. Protein coding regions occupy 61% o f the total DNA sequence. Within the intergenic regions, potential reg ulatory elements can be predicted. The data obtained here may serve as a basis for a more detailed biochemical analysis of the novel genes. The complete nucleotide sequence of the 26 kb segment as depicted in F igure 1 has been deposited at the EBI data library under Accession Num ber X91067.