ANALYSIS OF THE STABILITY OF SOME PROPERT IES OF TICK-BORNE ENCEPHALITIS-VIRUS (STRAIN-205) DURING PASSAGES IN MICE

Comparative analysis of the characteristics of tick-borne encephalitis (TEE) strain 205 used for the production of vaccine against TEE and o f its variants obtained by passages in mouse brain showed the stabilit y of such properties as infective activity, neurovirulence, sensitivit y to physical (heating to 50 C) and chemical (sodium deoxycholate trea tment) factors. At the same time, increased neurovirulence of variants 205/M10 and 205/M20, which undergone through 10 and 20 passages in wh ite mouse brain, for low-sensitive Syrian hamsters was revealed. Use o f a panel of 5 monoclonal antibodies to protein E and of 4 monoclonal antibodies to protein NS3 helped differentiate between not only strain s 205 and Sofyin, but between variants of strain 205 as well.