ASSESSMENT OF THE REACTOGENICITY AND ANTI GENIC ACTIVITY OF LIVE MEASLES-VACCINE LENINGRAD-16 IN DIFFERENT REGIONS

The reactogenicity and antigenic activity of live measles vaccine prep ared from strain Leningrad-16 were assessed for 4 territories, two of which were exposed to radiation contamination as a result of the Chern obyl accident. The study was carried out at the L. A. Tarasevich State Institute for Standardization and Control of Viral Preparations. The vaccine was weakly reactogenic in all the regions; no grave or uncommo n reactions to its administration were observed. Serologic studies rev ealed a high antigenic activity of the vaccine. The level of seroconve rsion was estimated as 98.5%. The study failed to detect any appreciab le effect of radiation contamination on the tolerance to vaccine or le vel of immune response.