The dielectrically consistent reference interaction site model theory
(DRISM) was used to calculate excess chemical potentials of solvation
for the immersion of a nonpolar solute molecule (Lennard-Jones sphere)
in a molecular model of water in a wide variety of state conditions.
The chemical potential was found to be predominantly entropic, In all
cases the chemical potential was found to consist almost entirely of a
solute surface area and a solute volume term. Both these terms were s
ignificant over a range of solute sizes and pressure/temperature state
s. It was concluded that the volume-dependent term must include contri
butions in addition to that from the system pressure. An exactly solva
ble lattice model of solvation was also investigated, and the model co
nditions for which the chemical potential becomes predominantly entrop
ic were determined. One situation was shown where a volume-dependent e
ntropic term in the chemical potential, other than pressure, arises.