Human T-cell lymphotropic virus type I (HTLV-I) has a worldwide distri
bution; infection rates of up to 14% have been found in Aboriginal com
munities, but there is little evidence of typical HTLV-I-associated di
sease. The strains among Australian Aboriginals and Melanesians are mo
re closely related to each other at the molecular level than to strain
s from Africa, Japan and the Caribbean basin. The clinical significanc
e of these Oceanic strains of HTLV-I in endemically infected communiti
es is unclear.