NEURONAL INTRANUCLEAR INCLUSION DISEASE - POLYMERASE CHAIN-REACTION AND ULTRASTRUCTURAL-STUDY OF RECTAL BIOPSY SPECIMEN IN A NEW CASE

We report the case of a boy with neuronal intranuclear inclusion disea se in whom the diagnosis was made by examination of a rectal biopsy sp ecimen. Intranuclear inclusions were observed in the Auerbach and Meis sner plexuses. In an attempt to understand the physiopathology of this very rare disease, we performed polymerase chain reaction (PCR) and r everse transcriptase-PCR analysis for viral nucleic acids of human imm unodeficiency virus type 1 (HIV-1), HIV-2, human cytomegalovirus and m easles virus. No viral nucleic acids were detected in the biopsy speci men.