DESIGN OF A HIGH-RESOLUTION IMAGE CYTOMETER WITH OPEN SOFTWARE ARCHITECTURE

A relatively inexpensive, non-proprietary high resolution color pathol ogy workstation is described. Hardware consists of a JVC frame capture camera with adjustable resolution up to 4416 x 3456, matching frame g rabber and a Unix workstation. Analytic software was developed using K horos 1.0.5, a powerful and flexible system for the development of ima ge analysis applications that is based on a visual programming languag e. Applications have been developed for DNA ploidy, quantitative immun ohistochemistry and texture and shape analysis. The instrument's softw are is uniquely extensible and transparent, and has been made publicly available over the Internet.