Postural sway testing was performed on 37 pesticide-exposed workers an
d 35 nonexposed subjects. All subjects were asymptomatic. When ratios
of sway measurements in different test conditions were investigated, t
otal length of sway was significantly different between groups (P = .0
001). Weight/height (P = .0006), exposure to pesticides (P = .0215), r
ecent organophosphate exposure (P =.0391), and plasma cholinesterase l
evel (P = .1537) were associated with increased body sway. The pattern
of sway performance suggested a proprioceptive impairment, well compe
nsated by visual cues, potentially attributable to pesticide exposure.
This finding is of unclear clinical significance because results of n
eurologic examinations and nerve conduction studies that were reported
separately did not show evidence of neuropathy. Postural sway testing
is a simple, sensitive, noninvasive, and reproducible technique to ev
aluate subtle neurologic dysfunction. These findings are preliminary.
Further studies are required to validate the findings and, if confirme
d, to explore their functional or clinical significance.