POLYCONDENSED NITROGEN-HETEROCYCLES .27. INDOLO[3,2-C]CINNOLINE - SYNTHESIS AND ANTILEUKEMIC ACTIVITY

Authors
CIRRINCIONE G ALMERICO AM DIANA P GRIMAUDO S DATTOLO G AIELLO E BARRAJA P MINGOLA F
Citation
G. Cirrincione et al., POLYCONDENSED NITROGEN-HETEROCYCLES .27. INDOLO[3,2-C]CINNOLINE - SYNTHESIS AND ANTILEUKEMIC ACTIVITY, Il Farmaco, 50(12), 1995, pp. 849-852
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
50
Issue
12
Year of publication
1995
Pages
849 - 852
Database
ISI
SICI code
0014-827X(1995)50:12<849:PN.I-S>2.0.ZU;2-W
Abstract
Indolo[3,2-c] cinnolines of type 5, variously substituted either in th e indole and in the cinnoline moieties, were prepared in good overall yields, by intramolecular cyclization of indolo derivatives 4. Compoun ds 5a-d showed a good cytotoxic activity against FLC and K562 leukemic cell lines, both sensitive and multi-drug resistant.