S. Bjurstrom et al., DISTRIBUTION AND MORPHOLOGY OF SKELETAL-MUSCLE LESIONS AFTER EXPERIMENTAL RESTRAINT STRESS IN NORMAL AND STRESS-SUSCEPTIBLE PIGS, Journal of veterinary medicine. Series A, 42(9), 1995, pp. 575-587
Six normal and 22 stress-susceptible (SS) pigs were subjected to exper
imental restraint stress to test the hypothesis that SS pigs are more
affected by stress-induced skeletal muscle lesions than normal pigs. T
he stress was provoked by a 12 min intravenous infusion of the myorela
xant succinylcholine at a dose which induced leg paralysis. At necrops
y 2-3 days after the stress, 24 muscles were examined macro- and micro
scopically. The plasma levels of noradrenaline and adrenaline increase
d significantly during the stress, especially in SS pigs. Significantl
y higher scores of acute muscle lesions (degeneration and phagocytosis
) were recorded in the SS pigs than in the normal pigs. The antebrachi
al flexor muscles, m. gastrocnemius, crural flexor muscles, m. serratu
s and m. intercostalis were most affected, while m. semitendinosus, m.
masseter, crural extensor muscles, m. quadriceps and antebrachial ext
ensor muscles were the least affected. The muscle regeneration of SS p
igs was greater than that of normal pigs indicating more active rhabdo
myolysis in SS pigs than in normal pigs. The muscle lesions were also
reflected in increased serum levels of creatine kinase(CK), aspartate
aminotransferase (ASAT), potassium and creatinine in SS pigs. It is co
ncluded that the restraint stress induced skeletal muscle lesions and
increased sympathetic activity, predominantly in SS pigs. It was also
shown that certain skeletal muscles are more affected by rhabdomyolysi
s than others.