INHIBITORY EFFECT OF A PICHIA-ANOMALA KILLER TOXIN ON PNEUMOCYSTIS-CARINII INFECTIVITY TO THE SCID MOUSE

Authors
SEGUY N CAILLIEZ JC POLONELLI L DEICAS E CAMUS D
Citation
N. Seguy et al., INHIBITORY EFFECT OF A PICHIA-ANOMALA KILLER TOXIN ON PNEUMOCYSTIS-CARINII INFECTIVITY TO THE SCID MOUSE, Parasitology research, 82(2), 1996, pp. 114-116
Citations number
16
Categorie Soggetti
Parasitiology
Journal title
Parasitology research → ACNP
ISSN journal
09320113
Volume
82
Issue
2
Year of publication
1996
Pages
114 - 116
Database
ISI
SICI code
0932-0113(1996)82:2<114:IEOAPK>2.0.ZU;2-O
Abstract
A Pichia anomala killer toxin has been demonstrated to have a specific inhibitory effect on the in vitro attachment of Pneumocystis carinii. The results presented herein show that this yeast toxin is also effec tive against P. carinii infectivity in reducing parasite colonization in the lungs of SCID mice. The specificity of this inhibitory effect w as controlled using a monoclonal antibody neutralizing the killer prop erties of the yeast toxin.