PROTON SELF-DIFFUSION IN MEMBRANES OF ERY THROCYTES AND GASTRIC MUCOUS CELLS IN SPONTANEOUSLY HYPERTENSIVE RATS

Proton pulsed nuclear magnetic resonance with pulsed magnetic field gr adient was used for the study of samples of gastric mucosa and erythro cytes obtained from spontaneously hypertensive (SHR) and normotensive rats of WKY line. The diffusion decay shape under the effect of magnet ic field gradient was different in hypertensive and normotensive rats both in gastric mucosa and in erythrocytes: the signal population of s low protons in hypertensive rats was lower than in normotensive animal s. Decrease in population of slow protons in tissues from spontaneousl y hypertensive rats confirmed the presence of ''defect'' of cellular m embranes in experimental primary arterial hypertension and could be ex plained by H+ leakage from cells when activation of Na+/H+ exchange ha d taken place.