THE ECOLOGY AND PATHOLOGY OF EPSTEIN-BARR-VIRUS

Authors
SCHMIDT CW MISKO IS
Citation
Cw. Schmidt et Is. Misko, THE ECOLOGY AND PATHOLOGY OF EPSTEIN-BARR-VIRUS, Immunology and cell biology, 73(6), 1995, pp. 489-504
Citations number
260
Categorie Soggetti
Cell Biology",Immunology
Journal title
Immunology and cell biology → ACNP
ISSN journal
08189641
Volume
73
Issue
6
Year of publication
1995
Pages
489 - 504
Database
ISI
SICI code
0818-9641(1995)73:6<489:TEAPOE>2.0.ZU;2-#
Abstract
Epstein-Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong pers istence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: lat ency in B lymphocytes and replication in epithelial cells. Both of the se cell compartments are potential sites for EBV-associated malignanci es.