RES-1149-1 AND RES-1149-2, NOVEL NONPEPTIDIC ENDOTHELIN TYPE-B RECEPTOR ANTAGONISTS PRODUCED BY ASPERGILLUS SP .1. TAXONOMY OF PRODUCING STRAIN, FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

Authors
OGAWA T ANDO K TANAKA T UOSAKI Y MATSUDA Y
Citation
T. Ogawa et al., RES-1149-1 AND RES-1149-2, NOVEL NONPEPTIDIC ENDOTHELIN TYPE-B RECEPTOR ANTAGONISTS PRODUCED BY ASPERGILLUS SP .1. TAXONOMY OF PRODUCING STRAIN, FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 49(1), 1996, pp. 1-5
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
1
Year of publication
1996
Pages
1 - 5
Database
ISI
SICI code
0021-8820(1996)49:1<1:RARNNE>2.0.ZU;2-M
Abstract
RES-1149-1 and -2, novel and non-peptidic endothelin antagonists, were isolated from the cultured broth of a fungus, Aspergillus sp. RE-1149 . RES-1149-1 and -2 selectively inhibited the ET-1 binding to endothel in type B receptor (ET(B) receptor) with IC50 values of 1.5 mu M and 2 0 mu M, respectively. Taxonomy of producing strains, fermentation, iso lation, and physico-chemical properties of RES-1149-1 and -2 are descr ibed.