IMMUNOHISTOCHEMICAL ANALYSIS OF BCL-2 AND P53 PROTEIN IN BREAST-CARCINOMA

Citation
M. Baba et al., IMMUNOHISTOCHEMICAL ANALYSIS OF BCL-2 AND P53 PROTEIN IN BREAST-CARCINOMA, International journal of oncology, 8(2), 1996, pp. 355-358
Citations number
27
Categorie Soggetti
Oncology
ISSN journal
10196439
Volume
8
Issue
2
Year of publication
1996
Pages
355 - 358
Database
ISI
SICI code
1019-6439(1996)8:2<355:IAOBAP>2.0.ZU;2-W
Abstract
We analyzed the expression of bcl-2 and p53 in relation to clinicopath ological features and estrogen receptor (ER) status in breast carcinom as from a series of 67 women who were treated surgically. Fifty and 23 cases showed positive immunostaining for bcl-2 and p53 protein, respe ctively. Thirty-five cases were ER-positive. A positive relationship w as observed between bcl-2 and ER (p<0.05). Furthermore, an inverse rel ationship was observed between bcl-2 and p53 (p<0.01), which suggests that overexpression of p53 may down-regulate bcl-2 expression in breas t carcinoma tissue, as has been described in a breast carcinoma cell l ine.