C. Latham et al., RELATIONSHIP BETWEEN ONCOGENE AMPLIFICATION, ANEUPLOIDY AND ALTERED EXPRESSION OF P53 IN BREAST-CANCER, International journal of oncology, 8(2), 1996, pp. 359-365
Many studies have noted an association between amplification of single
oncogenes and poor prognosis in breast cancer. We are investigating w
hether measurement of amplification in a larger number of proto-oncoge
nes increases the reliability of the prognostic information provided.
As the first stage of this investigation, amplification (of c-erbB-2,
cycD1, int-2, c-myc and MDM2), aneuploidy and altered expression of p5
3, which all indicate genetic instability, were studied in 117 primary
breast adenocarcinomas. Amplification was correlated with aneuploidy
(p=0.002) but not with altered expression of p53 even though the tumou
rs with p53 overexpression were all aneuploid. Our results suggest tha
t measurement of amplification is a potentially valuable prognostic fa
ctor.