We present a case report of a patient with clinical features suggestiv
e of pseudotumor cerebri (PTC), without a documented elevated measurem
ent of intracranial pressure (ICP). Chart review was done of one patie
nt's clinical course over a 28-month period. The patient was treated f
or PTC even though she never had a documented elevated ICP. Her signs
and symptoms, including headache, disc edema, and visual field loss, a
ll showed improvement with standard PTC therapy, which ultimately incl
uded optic nerve sheath fenestration (ONSF). Her presenting symptoms o
f clinical depression were also relieved with this treatment. PTC may
present without an elevated ICP as defined by current standards. Some
patients may be more susceptible to lower levels of ICP and develop th
is syndrome, and it may be responsive to standard PTC therapy. Further
investigation may warrant that clinical depression be included as ano
ther minor symptom of PTC.