Je. Wellington et al., EVIDENCE FOR INVOLVEMENT OF EQUINE HERPESVIRUS-1 GLYCOPROTEIN-B IN CELL-CELL FUSION, Archives of virology, 141(1), 1996, pp. 167-175
Monoclonal antibodies specific for equine herpesvirus 1 (EHV-1) glycop
roteins (gB, gD, gp2 and a cleaved translation product of gene 71) wer
e tested for ability to inhibit cell-cell fusion as measured by syncyt
ium formation in EHV-1 infected cell cultures. Syncytium formation was
inhibited by a complement-dependent neutralising antibody (7B10) whic
h recognised the large subunit of EHV-1 gB. This indicated that EHV-1
gB, in common with gB homologues of herpes simplex virus and other her
pesviruses, plays a role in the cell-cell fusion process.