11-BETA-ARYL STEROIDS IN THE ANDROSTENE SERIES - THE ROLE OF THE 11-BETA-REGION IN STEROID PROGESTERONE-RECEPTOR INTERACTION

Authors
CLEVE A FRITZEMEIER KH HEINRICH N KLAR U MULLERFAHRNOW A NEEF G OTTOW E SCHWEDE W
Citation
A. Cleve et al., 11-BETA-ARYL STEROIDS IN THE ANDROSTENE SERIES - THE ROLE OF THE 11-BETA-REGION IN STEROID PROGESTERONE-RECEPTOR INTERACTION, Tetrahedron, 52(5), 1996, pp. 1529-1542
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
5
Year of publication
1996
Pages
1529 - 1542
Database
ISI
SICI code
0040-4020(1996)52:5<1529:1SITAS>2.0.ZU;2-0
Abstract
The syntheses of 11 beta-arylandrost-4-en-3-one 24 and the correspondi ng 9 beta,19-cyclo derivative 8 are described Steric interaction betwe en C-19 and the aryl residue effects conformational changes of the ste roid ring system that result in reduced affinity for the progesterone receptor. The conformation of 11 beta-arylandrostenes is discussed in comparison with known antiprogestational steroids.