GLYCOLIPIDS FROM SPONGES .4. IMMUNOMODULATING GLYCOSYL CERAMIDES FROMTHE MARINE SPONGE AGELAS DISPAR

Authors
COSTANTINO V FATTORUSSO E MANGONI A DIROSA M IANARO A MAFFIA P
Citation
V. Costantino et al., GLYCOLIPIDS FROM SPONGES .4. IMMUNOMODULATING GLYCOSYL CERAMIDES FROMTHE MARINE SPONGE AGELAS DISPAR, Tetrahedron, 52(5), 1996, pp. 1573-1578
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
5
Year of publication
1996
Pages
1573 - 1578
Database
ISI
SICI code
0040-4020(1996)52:5<1573:GFS.IG>2.0.ZU;2-C
Abstract
The GSL composition of the marine sponge Agelas dispar was investigate d. In addition to four GSLs previously isolated from Agelas clathrodes (2 and 4), Agelas conifera (3), and Agelas longissima (5), the novel triglycosylceramide 1a was isolated as a major component of the GSL mi xture. All the isolated GSLs were tested using the MLR assay, and only some of them were shown to be immunoactivating agents, suggesting a p ossible structure-activity relationship.