NOVEL NONPROSTANOID PROSTACYCLIN (PGI(2)) MIMETICS WITH HETEROCYCLIC MOIETY

Authors
NAGAO Y TAKAHASHI K TORISU K KONDO K HAMANAKA N
Citation
Y. Nagao et al., NOVEL NONPROSTANOID PROSTACYCLIN (PGI(2)) MIMETICS WITH HETEROCYCLIC MOIETY, Heterocycles, 42(2), 1996, pp. 517-523
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
42
Issue
2
Year of publication
1996
Pages
517 - 523
Database
ISI
SICI code
0385-5414(1996)42:2<517:NNP(MW>2.0.ZU;2-M
Abstract
Structural modification of [2-(2-benzhydryloxyiminopentyl)- 1,2,3,4-te trahydro-5-naphthyloxy]acetic acid (4), previously identifed as a PGI( 2) agonist without a PG skeleton, was examined. Conversion of the oxim e moiety in 4 to the pyrazole led to yl)methyl-1,2,3,4-tetrahydro-5-na phthyl-oxy]acetic acid (34) which strongly inhibited ADP-induced aggre gation human platelets in vitro.