SYNTHESIS AND BIOLOGICAL EVALUATION OF SODIUM NYLMETHYL]-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLATE 1,1-DIOXIDE

Authors
SETTI EL PHILLIPS OA REDDY AVN KUNUGITA C HYODO A MICETICH RG MAITI SN
Citation
El. Setti et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF SODIUM NYLMETHYL]-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLATE 1,1-DIOXIDE, Heterocycles, 42(2), 1996, pp. 645-651
Citations number
3
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
42
Issue
2
Year of publication
1996
Pages
645 - 651
Database
ISI
SICI code
0385-5414(1996)42:2<645:SABEOS>2.0.ZU;2-R
Abstract
A new beta-lactamase inhibitor, sodium 2 beta-[(2,5-dihydro-6-hydroxy- 2-methyl-5-oxo-1, ,2,4-triazin-3-yl)sulfonylmethyl]-2 alpha-methylpena m-3 alpha-carboxylate 1,1-dioxide (3), was synthesized. The compound ( 3) had excellent in vitro inhibitory activity except against cephalosp orinase. In combination with ampicillin, piperacillin and ceftazidime, its synergistic effects was inferior to tazobactam, thus suggesting p oor penetration through the bacterial cell wall.