BETA-LACTAMASE INHIBITORS - SYNTHESIS AND IN-VITRO EVALUATION OF TITUTED-1,2,3-TRIAZOL-4-YL)METHYLENE]-PENICILLANIC ACID SULFONES

Authors
EBY P CUMMINGS MD PHILLIPS OA CZAJKOWSKI DP SINGH MP SPEVAK P MICETICH RG MAITI SN
Citation
P. Eby et al., BETA-LACTAMASE INHIBITORS - SYNTHESIS AND IN-VITRO EVALUATION OF TITUTED-1,2,3-TRIAZOL-4-YL)METHYLENE]-PENICILLANIC ACID SULFONES, Heterocycles, 42(2), 1996, pp. 653-668
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
42
Issue
2
Year of publication
1996
Pages
653 - 668
Database
ISI
SICI code
0385-5414(1996)42:2<653:BI-SAI>2.0.ZU;2-X
Abstract
A series of 6-[(1-substituted 1,2,3-triazol-4-yl)methylene]penicillani c acid sulfones were synthesized and tested for beta-lactamase inhibit ory activity. The (6Z)-isomers were over 100 times more potent than th e (6E)-isomers against cell-free beta-lactamases and were synergistic with ampicillin against a variety of beta-lactamase producing bacteria .