A. Ando et I. Kumadaki, SYNTHESIS OF FLUORINE ANALOGS OF NATURAL PORPHYRINS POTENTIALLY USEFUL FOR DIAGNOSIS AND THERAPY OF CANCER, Heterocycles, 42(2), 1996, pp. 885-899
Hematoporphyrin derivative (HpD) or Photofrin II are used for photosen
sitizer of photodynamic therapy (PDT) of cancer. However, these are co
mplex mixtures of porphyrin derivatives. We have synthesized fluorine
analogs of naturally important porphyrin derivatives, such as protopor
phyrin and hematoporphyrin, which would be useful for diagnosis and th
erapy of cancer. In this review, we wish to show our syntheses of thes
e fluorine analogs and the localization of these porphyrins to tumor c
ells and some tissues.