IMPUTABILITY OF HEPARIN IN HEPARIN-INDUCED THROMBOCYTOPENIA - A 10-YEAR EXPERIENCE OF THE CENTER-REGIONAL-DE-PHARMACOVIGILANCE OF REIMS-CHAMPAGNE ARDENNE

The imputability of heparin in heparin induced thrombocytopenia (HIT) was analysed retrospectively in the chart records of 86 cases document ed by the Centre Regional de Pharmacovigilance (CRPV) of Reims-Champag ne Ardenne over a period of 10 years. Considerable difficulties are en countered in evaluating the degree of imputability. Chronological crit eria seem to be determinant in the final imputability score, whereas s emiological criteria are particularly difficult to interpret, especial ly as it is not yet clearly established whether biological tests shoul d be taken into account. The method of assessment requires more precis e adaptation to the specific case of HIT and could be improved by rede finition of the criteria in collaboration between pharmacologists and haematologists.