LATERITIN, A NEW INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY GIBBERELLA-LATERITIUM IFO-7188

A new inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), design ated lateritin, was isolated from the mycelial cake of Gibberella late ritium IFO 7188 by successive purification procedure of solvent extrac tion, silica gel column chromatography and reverse phase HPLC. Spectro scopic analyses of the compound yielded thyl)-3-phenylmethyl-1,4-perhy drooxazine-2,5-dione as the proposed structure. Lateritin inhibited ra t liver ACAT activity by 50% at a concentration of 5.7 mu M. This inhi bition was time-dependent and irreversible.