THIOMARINOL, A NEW HYBRID ANTIMICROBIAL ANTIBIOTIC PRODUCED BY A MARINE BACTERIUM FERMENTATION, ISOLATION, STRUCTURE, AND ANTIMICROBIAL ACTIVITY

Thiomarinol, an antimicrobial antibiotic, was isolated from the cultur e broth of a marine bacterium, Alteromonas rava sp. nov. SANK 73390. I ts structure was deduced as a hybrid composed of a pseudomonic acid an alogue and holothin by NMR spectral analysis and chemical degradation. Antimicrobial activity against Gram-positive and Gram-negative bacter ia of thiomarinol was stronger than both of pseudomonic acids and pyrr othine antibiotics.