SYNTHESIS OF 3-EPISIASTATIN B ANALOGS HAVING ANTIINFLUENZA VIRUS ACTIVITY

Authors
NISHIMURA Y UMEZAWA Y KONDO S TAKEUCHI T MORI K KIJIMASUDA I TOMITA K SUGAWARA K NAKAMURA K
Citation
Y. Nishimura et al., SYNTHESIS OF 3-EPISIASTATIN B ANALOGS HAVING ANTIINFLUENZA VIRUS ACTIVITY, Journal of antibiotics, 46(12), 1993, pp. 1883-1889
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
12
Year of publication
1993
Pages
1883 - 1889
Database
ISI
SICI code
0021-8820(1993)46:12<1883:SO3BAH>2.0.ZU;2-A
Abstract
Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastati n B (4), were obtained by the chemical modification of siastatin B. Co mpound 3 showed marked inhibitory activity against influenza virus neu raminidases and significant inhibition of influenza virus infection in vitro.