ANTIEPILEPTIC EFFECTS OF ACIDIC FIBROBLAST GROWTH-FACTOR EXAMINED IN KAINIC ACID-MEDIATED SEIZURES IN THE RAT

Authors
CUEVAS P GIMENEZGALLEGO G
Citation
P. Cuevas et G. Gimenezgallego, ANTIEPILEPTIC EFFECTS OF ACIDIC FIBROBLAST GROWTH-FACTOR EXAMINED IN KAINIC ACID-MEDIATED SEIZURES IN THE RAT, Neuroscience letters, 203(1), 1996, pp. 66-68
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
203
Issue
1
Year of publication
1996
Pages
66 - 68
Database
ISI
SICI code
0304-3940(1996)203:1<66:AEOAFG>2.0.ZU;2-3
Abstract
The possibility that exogenous recombinant human acidic fibroblast gro wth factor (rhaFGF) may have anticonvulsant properties was investigate d in a model of temporal lobe epilepsy in awake rats. We found that af ter intraperitoneal injection of rhaFGF in kainic acid-treated rats, t onic-clonic convulsions and mortality were decreased by 74% and 77%, r espectively. These results are consistent with previous studies showin g a neuroprotective effect of FGF against insults to the brain and sup port a possible therapeutic role for FGF in the treatment of excitotox ic processes.