MITOCHONDRIAL DEFECTS IN BASAL GANGLIA DISEASES

Authors
SHOFFNER JM
Citation
Jm. Shoffner, MITOCHONDRIAL DEFECTS IN BASAL GANGLIA DISEASES, Current opinion in neurology, 8(6), 1995, pp. 474-479
Citations number
81
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
Current opinion in neurology → ACNP
ISSN journal
13507540
Volume
8
Issue
6
Year of publication
1995
Pages
474 - 479
Database
ISI
SICI code
1350-7540(1995)8:6<474:MDIBGD>2.0.ZU;2-P
Abstract
Mitochondrial DNA mutations are important causes of movement disorders and are often associated with basal ganglia degeneration. Leigh's dis ease and a form of generalized dystonia are caused by mitochondrial DN A mutations. Recent biochemical and genetic evidence suggests that som e cases of Parkinson's disease may be caused by oxidative phosphorylat ion defects.