A FATAL DOTHIEPIN OVERDOSE

Authors
CIRIMELE V KINTZ P TRACQUI A MANGIN P
Citation
V. Cirimele et al., A FATAL DOTHIEPIN OVERDOSE, Forensic science international, 76(3), 1995, pp. 205-209
Citations number
19
Categorie Soggetti
Medicine, Legal
Journal title
Forensic science international → ACNP
ISSN journal
03790738
Volume
76
Issue
3
Year of publication
1995
Pages
205 - 209
Database
ISI
SICI code
0379-0738(1995)76:3<205:AFDO>2.0.ZU;2-S
Abstract
High pressure liquid chromatography coupled to photodiode array detect or and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (Prothiaden(R)) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concent ration of 1.89 ng/mg hair. Results are discussed in the light of the e xisting literature.