From its origin the Protein Sequence Database has been designed to sup
port research and has focused on comprehensive coverage, quality contr
ol and organization of the data in accordance with biological principl
es. Since 1988 the database has been maintained collaboratively within
the framework of PIR-lnternational, an association of macromolecular
sequence data collection centers dedicated to fostering international
cooperation as an essential element in the development of scientific d
atabases. The database is widely distributed and is available on the W
orld Wide Web, via ftp, email server, on CD-ROM and magnetic media. It
is widely redistributed and incorporated into many other protein sequ
ence data compilations, including SWISS-PROT and the Entrez system of
the NCBI.