THE SBASE PROTEIN DOMAIN LIBRARY, RELEASE-4.0 - A COLLECTION OF ANNOTATED PROTEIN-SEQUENCE SEGMENTS

SBASE 4.0 is the fourth release of SBASE, a collection of annotated pr otein domain sequences that represent various structural, functional, ligand binding and topogenic segments of proteins, SBASE was designed to facilitate the detection of functional homologies and can be search ed with standard database search tools, such as FASTA and BLAST3, The present release contains 61 137 entries provided with standardized nam es and cross-referenced to all major protein, nucleic acid and sequenc e pattern collections. The entries are clustered into 13 155 groups in order to facilitate detection of distant similarities, SBASE 4.0 is f reely available by anonymous ftp file transfer from ftp.icgeb.trieste. it. Individual records can be retrieved with the gopher server at icge b.trieste.it and with a World Wide Web server at http://www.icgeb.trie ste.it. Automated searching of SBASE with BLAST can be carried out wit h the electronic mail server sbase@icgeb.trieste.it, which now also pr ovides a graphic representation of the homologies, A related mail serv er, domain @hubi.abc.hu, assigns SBASE domain homologies on the basis of SWISS-PROT searches.