HISTONE SEQUENCE DATABASE - A COMPILATION OF HIGHLY-CONSERVED NUCLEOPROTEIN SEQUENCES

By searching the current protein sequence databases using sequences fr om human and chicken histones H1/H5, H2A, H2B, H3 and H4, a database o f aligned histone protein sequences with statistically significant seq uence similarity to the search sequences was constructed, In addition, a nucleotide sequence database of the corresponding coding regions fo r these proteins has been assembled, The region of each of the core hi stones containing the histone fold motif is identified in the protein alignments. The database contains >1300 protein and nucleotide sequenc es, All sequences and alignments in this database are available throug h the World Wide Web at http://www.ncbi.nlm.nih.gov/Baxevani/HISTONES.