M. Haghbin et al., CORRELATION OF FLOW-CYTOMETRY TO CLINICAL FACTORS, HORMONE RECEPTORS,AND HISTOPATHOLOGICAL GRADE IN STAGE-I AND STAGE-II INVASIVE BREAST-CARCINOMA, American journal of clinical oncology, 19(1), 1996, pp. 54-58
DNA index (ploidy) and S-phase fraction (SPF) were measured by flow cy
tometry in 131 invasive stage I and II breast carcinomas. Ploidy showe
d a strong correlation with SPF (p = 0.0001), with aneuploid tumors ha
ving a high SPF. Both cytometric parameters correlated with tumor size
and hormonal receptor status. Smaller tumors tended to be diploid and
have low SPF. Nodal status did not demonstrate an association with cy
tometric findings. There was a highly significant connection between t
umor grade, especially nuclear grade, and SPF (p = 0.0001). The study
demonstrates the relationship between conventional prognostic factors,
DNA content, and proliferative activity of breast tumors.