LIPID-PEROXIDATION IN CORD-BLOOD AT BIRTH

OBJECTIVE: The purpose of this study was to determine oxygen free radi cal activity in the neonate at birth and relate it to umbilical cord b lood acid-base status. STUDY DESIGN: A series of 110 singleton deliver ies had determination of two lipoperoxides in umbilical cord blood: ma londialdehyde and organic hydroperoxide. Umbilical pH, Po-2, Pco(2), b icarbonate, and base excess were also measured.RESULTS: There was a si gnificant association between lipoperoxides and cord blood pH and base excess. A significant difference existed in the levels of umbilical a rtery lipoperoxides between nonacidemic and acidemic fetus, as defined by an umbilical arterial pH <7.20. CONCLUSION: There is a positive as sociation between lipoperoxide production and acid-base balance at del ivery.