ALTERATIONS IN ANTERIOR SEGMENT DIMENSIONS IN EYES WITH RETINITIS-PIGMENTOSA

Background: In visually deprived primate eyes there is a correlation b etween alterations in growth parameters and changes in retinal neurotr ansmitters. Progressive retinal degeneration also leads to alterations in retinal neurotransmitters. In this study we wanted to investigate whether alterations in the dimensions of the anterior eye segment are also present in human donor eyes of patients with hereditary retinal d egeneration. Methods: Sagittal sections through anterior segments of 4 7 eyes from donors with different types of retinitis pigmentosa (RP) a nd of 59 eyes from normal donors were investigated morphometrically us ing a PC-based morphometric system. Results: In the RP eyes there was a significant shortening of the distance between the peripheral end of Descemet's membrane and the posterior end of Schlemm's canal and of t he length of the pars plana of the ciliary body. These different types of RP. The most pronounced shortenings were found in eyes of men with X-linked recessive RP, which had the most severe retinal changes. RP eyes showed, in contrast to normal eyes, significant age-related elong ation of the ciliary body and the chamber angle. A significant increas e of the axial diameter with age was also found in RP eyes. Conclusion : Our study reveals for the first time that there are changes in the a nterior segment dimensions in human eyes with hereditary retinal degen eration. Measurements of anterior eye segment parameters might provide additional indices for the severity of RP and for the diagnosis of RP subtypes.