FLUCONAZOLE IN THE THERAPY OF TROPICAL DEEP MYCOSES

A clinical study was conducted to test the efficacy of fluconazole in the treatment of tropical deep mycoses. Two out of four patients with zygomycosis due to Conidiobolus coronatus who were treated with the dr ug were completely cured; the other two patients exhibited considerabl e improvement but could not be followed up. Two patients with eumyceto ma, one due to an Acremonium sp. and one due to Pseudallescheria boydi i, were treated successfully, whereas another patient with a eumycetom a caused by an unidentified fungus could not be followed up. A complet e cure was achieved with one patient with African histoplasmosis and o ne with candiduria. A case of cerebral phaeohyphomycosis due to Clados porium sp. showed some improvement but the patient later developed men ingitis and died.